| CAS No.: | 330936-70-4 |
|---|---|
| Formula: | C118h202n34o31s2 |
| EINECS: | N/a |
| Type: | Peptides Powder |
| Appearance: | Powder |
| Quality: | Top Quality |
| Samples: |
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| Customization: |
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| Product name | Humanin |
| Appearance | White powder |
| Purity | 99% |
| Storage | Keep in a cool, dry, dark location in a tightly sealed container or cylinder. |
| Shelf Life | 24 Months |
Description
Humanin is a micro-peptide, which means it is produced by short, open reading frames and does not undergo
modification once produced. According to studies, this type of peptide ranges in size from 100-150 amino acids
in length.
At only 24 amino acids in length, Humanin is actually one of the smallest micropeptides available. Its main feature
is its interaction with the Bax protein to regulate apoptosis, eliminating the function of it when needed to preserve cells.
Humanin (HN) is a polypeptide and a naturally occurring micro-peptide which suppresses neuronal cell death
induced by various Alzheimer's disease genes as studies showed. The Humanin peptide is encoded in the
mitochondrial DNA[i] and functions as a cytoprotective protein, protecting cells from apoptosis. Apoptosis is
programmed cell death. By protecting the cells from this lethal process, it keeps the cells healthy and protects
neurons, muscle cells, cardiac tissue, and the retina of the eye as tests showed.
Research shows that humanin treatment can improve cardiovascular disease and Alzheimer's disease. With
more extensive research, it could soon become an available over-the-counter medication for such health
conditions.
Application&Function
Humanin is an endogenous mitochondria-derived peptide that has cytoprotective effects and reduces oxidative
stress. Experiments using cultured cells have demonstrated that humanin has both neuroprotective as well as
cytoprotective effects and experiments in rodents have found that it has protective effects in Alzheimer's disease
models, Huntington's disease models and stroke models. Humanin is proposed to have myriad neuroprotective
and cytoprotective effects.
Both studies in cells and rodents have both found that administration of humanin or humanin derivatives increases
survival and/or physiological parameters in Alzheimer's disease models.
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