Manufacturer Sales Price Anti-Cancer Custom Synthesis Peptides Pnc-27 99% Pure Pharmaceutical Intermediates Pnc 27 Powder

• Customization: Available
• CAS No.: 67727-97-3
• Formula: C187h291n45o59
• Model NO.: Pnc-27
• Type: Peptides Powder
• Appearance: Powder
• Quality: Top Quality
• Colour: White
• Name: Pnc-27
• Mf: C187h291n45o59
• MW: 4113.57754
• CAS: 67727-97-3
• Packing: 1kg/Foil Bag or 25kgs/Drum
• Usage: for Research Use Only
• Transport Package: as Customers′ Requirement
• Specification: 1G/Foil bag
• Trademark: RDG
• Origin: China

Product Description

Manufacturer Sales Price Anti-Cancer Custom Synthesis Peptides Pnc-27 99% Pure Pharmaceutical Intermediates Pnc 27 Powder

Product name	PNC-27
Appearance	White powder
Purity	99%
Storage	Keep in a cool, dry, dark location in a tightly sealed container or cylinder.
Shelf Life	24 Months

Product Name: PNC-27
CAS No:N/A
Sequence:N/A
Molecular Formula: N/A
Molecular Weight: N/A
Specification: 1g/Bottle
Purity : 98% HPLC
Appearance:  White Powder
Shelf Life:24 Month
Storage: Refrigeration keeps dry and away from light.

Application
 

The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of

p53 and a transmembrane-penetrating domain, has been found to kill cancer cells (but not normal cells) by

inducing membranolysis. We find that our previously determined 3D structure of the p53 residues of PNC-27 is

directly superimposable on the structure for the same residues bound to HDM-2, suggesting that the peptide may

target HDM-2 in the membranes of cancer cells.

Product Benefits:

We now find significant levels of HDM-2 in the membranes of a varietyof cancer cells but not in the membranes of

several untransformed cell lines. In colocalization experiments, we find that PNC-27 binds to cell membrane-bound

HDM-2. We further transfected a plasmid expressing full-length HDM-2 with a membrane-localization signal into

untransformed MCF-10-2A cells not susceptible to PNC-27 and found that these cells expressing full-length HDM-2

on their cell surface became susceptible to PNC-27. We conclude that PNC-27 targets HDM-2 in the membranes of

cancer cells, allowing it to induce membranolysis of these cells selectively.

 

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