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Audited Supplier | Product name | Clobetasol Propionate |
| CAS no. | 25122-46-7 |
| Formula | C25H32ClFO5 |
| Molecular Weight | 466.97 |
Description
Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory,
anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic
glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results
in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.
Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the
release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase.
Application&Function
Clobetasol propionate is a corticosteroid used to treat various skin disorders including eczema and psoriasis. It is
also highly effective for contact dermatitis caused by exposure to poison ivy/oak.
Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available.
It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically
should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used
to treat several auto-immune diseases including alopecia areata,vitiligo and lichen planus (auto immune skin nodules).
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Audited Supplier 
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